Successful preimplantation genetic diagnosis to avoid creating a child affected by a genetically-based disorder was reported in 1989. Since then PGD has been used to biopsy and analyze embryos created through in viuo fertilization to avoid transferring to the mother’s uterus an embryo affected by a mutation or chromosomal abnormality associated with serious illness. PGD to avoid serious and early-onset illness in the child-to-be is widely accepted. PGD prevents gestation of an affected embryo and reduces the chance that the parents (...) will be faced with a difficult decision of whether to terminate the pregnancy. More controversial have been PGD to select the sex of the child-to-be for “family balancing”, PGD for mere susceptibility to disease and for late-onset disorders such as Alzheimer diseas, and most controversially, PGD to create a donor child who is Human Leukocyte Antigen (HLA-matched with a preexisting sibling in need of stem cell transplant. (shrink)

Understanding the evolutionary role of environmentally induced phenotypic variation (i.e., plasticity) is an important issue in developmental evolution. A major physiological response to environmental change is cellular stress, which is counteracted by generic stress reactions detoxifying the cell. A model, stress‐induced evolutionary innovation (SIEI), whereby ancestral stress reactions and their corresponding pathways can be transformed into novel structural components of body plans, such as new cell types, is described. Previous findings suggest that the cell differentiation cascade of a cell type (...) critical to pregnancy in humans, the decidual stromal cell, evolved from a cellular stress reaction. It is hypothesized that the stress reaction in these cells was elicited ancestrally via inflammation caused by embryo attachment. The present study proposes that SIEI is a distinct form of plasticity‐based evolutionary change leading to the origin of novel structures rather than adaptive transformation of pre‐existing characters. (shrink)

“A fine collection of essays exploring, and in many cases extending, Jim Buchanan’s many contributions and insights to economic, political, and social theory.”– Bruce Caldwell, Professor of Economics, Duke University, USA"The overwhelming impression the reader gets from this very fine collection is the extraordinary expanse of James Buchanan's work. Everyone interested in economics and related fields can profit mightily from this book."– Mario Rizzo, Professor of Economics, New York University, USA This book explores the academic contribution of James Buchanan, who (...) received the Nobel Prize for economics in 1986. Buchanan’s receipt of the Prize is noteworthy because he was a maverick within the economics profession. In contrast to the preponderance of economists, Buchanan made little use of mathematics and no use of econometrics, preferring to used logic and language to insert his ideas into the scholarly community. Moreover, his ideas extended the domain of economic inquiry along many paths that numerous economists subsequently pursued. Buchanan’s scholarship brought economics and political science together under the rubric of public choice. He was also was a prime figure in bringing economic theory into closer contact with moral and social philosophy.This volume includes essays distributed across the extensive domain of Buchanan’s scholarly contributions, reflecting the range of his scholarly interests. Chapters will examine Buchanan’s scholarly work on public finance, social insurance, public debt, public choice, economic methodology, constitutional political economy, law and economics, and ethics and social theory. The book also examines Buchanan in relation to other prominent economists, both from the distant past and the recent past. (shrink)

This essay introduces a collection of 49 essays that exemplify the breadth and the depth of James M. Buchanan’sBuchanan, James M. contributions to economics in the post-war period. Buchanan started his career in 1948 as someone who wanted to provide a different scholarly framework for a theory of public finance and managed to do so. What resulted was a scholarly output that was published in 20 volumes in 2002, to which he continued to add until his death. The essays in (...) this volume reflect the breadth and depth of Buchanan’s contributions to political economy and social philosophy. While these essays are written by people who admired and learned from Buchanan’s work, these are not essays in hagiography. They explore various questions and topics that interested Buchanan. A good number of these explorations have critical overtones, but most significantly they build upon lines of inquiry that animated Buchanan’s scholarly curiosity. (shrink)

Nicholas Vriend asked whether F.A. Hayek was an “ace,” and answered affirmatively. By “ace,” Vriend meant someone who worked with agent-based modeling. To be sure, Hayek could not have worked with agent-based models because that platform did not exist when Hayek was developing his ideas about the distribution and use of knowledge in society. All the same, Vriend explained convincingly that Hayek could have made good use of the agent-based platform had it been available in the 1930s. To similar effect, (...) we argue in this paper that James Buchanan could have made good use of agent-based modeling to carry forward his ideas about the value of taking an emergent approach to the explanation of economic processes. (shrink)

In this paper, the relationship between the e-value of a complex hypothesis, H, and those of its constituent elementary hypotheses, Hj, j = 1… k, is analyzed, in the independent setup. The e-value of a hypothesis H, ev, is a Bayesian epistemic, credibility or truth value defined under the Full Bayesian Significance Testing mathematical apparatus. The questions addressed concern the important issue of how the truth value of H, and the truth function of the corresponding FBST structure M, relate to (...) the truth values of its elementary constituents, Hj, and to the truth functions of their corresponding FBST structures Mj, respectively. (shrink)

It is nearly universally presumed that redistribution can be carried out effectively only at the national or even global level, because local redistribution will be negated through personal mobility: recipients will move to high-paying jurisdictions while taxpayers will move away from those jurisdictions. To avoid this situation requires redistribution to be concentrated at national and not at local levels. In contrast to this standard line of argument, we explore how redistribution might be carried out more effectively at local levels than (...) at the national level. To explain this reversal from standard analytical implications, we integrate three concepts that are not present in the standard analysis. These concepts are the Samaritan’s dilemma, co-production, and polycentricity. It is interaction among these three concepts that reverses the implications of the standard analysis of redistribution. (shrink)

This volume contains the proceedings of JELIA '92, les Journ es Europ ennes sur la Logique en Intelligence Artificielle, or the Third European Workshop on Logics in Artificial Intelligence. The volume contains 2 invited addresses and 21 selected papers covering such topics as: - Logical foundations of logic programming and knowledge-based systems, - Automated theorem proving, - Partial and dynamic logics, - Systems of nonmonotonic reasoning, - Temporal and epistemic logics, - Belief revision. One invited paper, by D. Vakarelov, is (...) on arrow logics, i.e., modal logics for representing graph information. The other, by L.M. Pereira,J.J. Alferes, and J.N. Apar cio, is on default theory for well founded semantics with explicit negation. (shrink)

This Festschrift is one of the best we have been offered during the last decade. German, French, Turkish, Italian, South African, and Austrian scholars have written 23 essays in honor of one of the foremost historians of philosophy in this century, H. Heimsoeth. Half of the book is devoted to Kantian-scholarship; especially impressive are: Guéroult's study on the structure of the second analogy of experience, Belaval's comparison between Kant and Leibniz, and the richly documented long investigation by G. Tonelli on (...) the presuppositions of Kant's table of judgments in the logic of the eighteenth century. The second part of the present volume is more heterogeneous than the first. One reads with genuine enthusiasm H. Fuhrmans' "The God-World relationship in Schelling's late philosophy." L. Landgrebe's article on the philosophical problem of the end of history is grounded in Kantian soil, but other essays are little connected to Heimsoeth's major interests. These essays include: E. Lichtenstein on the philosophical development of the concept of culture from Meister Eckhart to Hegel; F. Nicolin on the systematic situation of the history of pedagogy since Herbart and Schleiermacher; and H. Wagner's paper on Plato and the beginning of metaphysics as a science. The book concludes with a rich bibliography of Heimsoeth's publications since 1911.--M. J. V. (shrink)

Book Reviewed in this article: Israel's Prophetic Tradition: Essays in honour of Peter R. Ackroyd. Edited by Richard Coggins, Anthony Phillips and Michael Knibb, Pp.xxi, 272. Cambridge University Press, 1982, £21.00. Essays on John. By C.K. Barrett. Pp.viii, 167, London, SPCK, 1982, £10.50. The Letter to the Colossians. By Eduard Schweizer, translated by Andrew Chester. Pp.319, London, SPCK, 1982, £12.50. Foundational Theology: Jesus and the Church. By Francis Schüssler Fiorenza. Pp.xix, 326, New York Crossroad, 1984, $22.50. The Darkness of God: (...) Theology after Hiroshima. By Jim Garrison. Pp.x, 238, London, SCM Press, 1982, £5.95. Discerning the Mystery, An Essay on the Nature of neology. By Andrew Louth. Pp.xiv, 150, Oxford, Clarendon Press, 1983, £12.50. The Tao and the Daimon: Segments of a Religious Inquiry. By Robert C. Neville. Pp.xv, 281, Albany, New York, State University of New York Press, 1982, $34.50 ), $11.95. Person and Myth: Maurice Leenhardt in the Melanesian World. By James Clifford. Pp.xi, 270, Berkeley, University of California Press, 1982, £21.50. Transcendence and the Sacred. Edited by A.M. Olson and L.S. Rouner. Pp.xv, 230, University of Notre Dame Press, 1981, £10.75. A History of Religious Ideas. Vol. 2: From Gautama Buddha to the Triumph of Christianity. By Mircea Eliade. Translated by William R. Trask. Pp.xi, 565, Chicago, University of Chicago Press, 1982, £17.50. Ordeal by Labyrinth: Conversations with Claude‐Henri Racquet. By Mircea Eliade. Translated by Derek Coltman. Pp.ix, 225, Chicago, University of Chicago Press, 1982, £12.55. Religious Philosophy of Prince‐Bishop Njegosh of Montenegro. By Zika Rad. Prvulovich. Pp.xviii, 273, Birmingham, The Author, 1984, £12.50, £10.50. The Home of Meaning: The Hermeneutics of the Subject of Paul Ricoeur. By John W. Van Dengel. Pp.xxi, 333, Washington, D.C., University Press of America, 1982, $24.50, $13.25. Life Forms and Meaning Stucture. By Alfred Schutz, translated, introduced and annotated by Helmut Wagner. Pp.vi, 217, London, Routledge & Kegan Paul, 1982, £11.95. The Shaping of Man: Philosophical Aspects of Sociobiology. By Roger Trigg. Pp.xx, 186. Oxford, Basil Blackwell, 1982, £12.50, £5.95. Marx and Marxisms: Royal Institute of Philosophy Lecture Series, 14. Edited by G.H.R. Parkinson. Pp.vi, 268, Cambridge University Press, 1982, £9.95. Marx and Justice: The Radical Critique of Liberalism. By Allen E. Buchanan. Pp.xiv, 206, London, Methuen, 1982, £12.95. Israel Satanter: Text, Structure, Idea. By Hillel Goldberg. Pp.xvii, 358, New York, Ktav, 1981, $17.50. Freud on Femininity and Faith. By Judith Van Herik. Pp.xiii, 216, Berkeley, University of California Press, 1982, £17.50. Women, Reason and Nature. By Carol McMillan. Pp.x, 165, Oxford, Basil Blackwell, 1982, £12.50. Supererogation: Its Status in Ethical Theory. By David Heyd. Pp.vii, 191, Cambridge University Press, 1982, £14.00. The Cambridge History of Later Medieval Philosophy. Edited by Norman Kretzmann, Anthony Kenny and Jan Finborg. Pp.xi, 1035, Cambridge, Cambridge University Press, 1982, £40.00. St Thomas Aquinas. By Ralph McInerny. Pp.197, Notre Dame, University of Notre Dame Press, 1982, £4.50. Yves de Vallone: The Making of an Esprit‐Fort. By James O'Higgins, S.J. Pp.viii, 248, The Hague, Martinus Nijhoff, 1982, $35.00. Religion and National Identity. Edited by Stuart Mews. Pp.xvi, 618, Oxford, Basil Blackwell, 1982, £19.50. Mortmain Legislation and the English Church, 1279–1500. By Sandra Raban. Pp.xii, 215,, Cambridge University Press, 1982, £25.00. John XXIII, Pope of the Council. By Peter Hebblethwaite. Pp.viii, 550, London, Geoffrey Chapman, 1984, £14.95.iCompiled by J.F. Púglisi and S.J. Voicu. Pp.260, Rome, Centro Pro Unione, 1984, $20.00. Ireland: A Bibliography of Material held at St Deiniol's Library. Compiled by Helen C. Price. Pp.iv, 136, Hawarden, St Deiniol's, 1984, £2.50. The Later Poems, 1972–1982. By R.S. Thomas. Pp.224, London, Macmillan, 1984, £4.95. (shrink)

Articles by Castelli, Dempf, de Corte, del Noce, Garin, Gigon, Gouhier, Guéroult, Husserl, Lombardi, Valori, and Wagner on a variety of topics pertinent to the philosophy of history, such as myth and history, legitimacy of the philosophy of history, and historic intention. Of special interest is a commentary and French translation by M. Valori of two unpublished manuscripts of Husserl. In these manuscripts one can see how Husserl views the place of phenomenological study in the history of philosophy since (...) Descartes.--J. E. B. (shrink)

Vidkun Quisling, who after World War II was executed as a traitor to his country/Norway, offers an unusual opportunity to reach the deepest layers of a Nazi mind-set, for he was also a closet philosopher. Was Quisling a genius, as some revisionists will have it? What did the original Quisling think? How did he think? A Nazi Interior deals with Quisling's own all-embracing philosophy, which he called « Universism. The author identifies Quisling's sources from early Christianity to the twentieth century (...) and analyses his very mode of thought. Barth is the first philosopher to deal with this matter. This book is constructed around twenty-eight basic themes central to Quisling's thought. Many of the conclusions come as a surprise. The author offers clear surveys of the elements of Quisling's mind-set and shows the effects of their interaction. (shrink)

Se comparten experiencias áulicas de la Universidad Nacional de Rosario, Argenti- na. Su objetivo es crear un instrumento para evaluar la riqueza creativa en diseño mecánico, con un método exploratorio y propositivo de validación de instrumentos y pruebas piloto sobre 156 estudiantes. Resultaron de imaginar objetos diversos, compatibles con una vista dada, y definir cinco niveles de riqueza según la canti- dad, diversidad y calidad de respuestas comparadas contra un patrón de soluciones creado por expertos. Se ensayaron cambios de duración, (...) complejidad de estímulos y presencia de soluciones preexistentes que confirmaron su potencial para investigar la creatividad en este dominio específico. (shrink)

Synaesthesia is a condition in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces photisms, i.e. mental percepts of colours. R is a 20 year old colour blind subject who, in addition to the relatively common grapheme-colour synaesthesia, presents a rarely reported cross modal perception in which a variety of visual stimuli elicit aura-like percepts of colour. In R, photisms seem to be closely related to the affective valence of stimuli and (...) typically bring out a consistent pattern of emotional responses. The present case study suggests that colours might be an intrinsic category of the human brain. We developed an empirical methodology that allowed us to study the subject's otherwise inaccessible phenomenological experience. First, we found that R shows a Stroop effect elicited by photisms despite the fact that he does not show a regular Stroop with real colours. Secondly, by manipulating the colour context we confirmed that colours can alter R's emotional evaluation of the stimuli. Furthermore, we demonstrated that R's auras may actually lead to a partially inverted emotional spectrum where certain stimuli bring out emotional reactions opposite to the normal ones. These findings can only be accounted for by considering R's subjective colour experience or qualia. Therefore the present paper defends the view that qualia are a useful scientific concept that can be approached and studied by experimental methods. (shrink)